Philip Awadalla Laboratory
Philip Awadalla - Malaria

> Research

We investigate the underlying genetic and environmental determinants of human phenotypes and diseases, with a focus on processes associated with aging, chronic diseases, cancer and infectious agents. Using genomic data from next-generation re-sequencing data, along with modern statistical tools, we are able to map and annotate function of genomic regions associated with disease pathology and virulence, as well as study the mechanisms that cause the mutations.

Philip Awadalla is PI of the Ontario Health Study;, and the CARTaGENE project in Quebec; and is Director of the Canadian Data Integration Centre. The Canadian Data Integration Centre is a Canada’s Big Data platform supporting research and access to large population cohort data, including genomic and phenotypic data, linkage to clinical outcomes, and data generation and collection working in collaboration with clinicians and medical scientists internationally.

Our ongoing projects include:

  • Next-generation sequencing and development of parametric and non-parametric population models/tools to study the role of genetic variants in cancer.
  • Implementing models to interrogate genomes to capture de novo mutations in families or large genomic studies.
  • The impact of population history on distribution of disease and damaging mutations. 1000 Genomes Project.
  • Genomic and Gene Regulation studies to capture and examine the impact of variants and genomic rearrangements in large population cohorts in Canada and across Africa.
  • Evolution and variation in recombination rates between populations, families and gametes.
  • Molecular and statistical genomic epidemiology projects across Canada.
  • Genome sequencing of new and old-world isolates of Plasmodium falciparum and related malaria species.
  • The impact of rare and de novo mutations on neurologic traits.